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The joint, a redox sensitive microenvironment?–an hypothesis.


Scand J Rheumatol Suppl Vol. 101 pp. 131-6


DATE: 1995


Antioxidant depletion in a normal adult increases the risk of developing rheumatoid arthritis (1). We discuss how redox processes “control” the inflammatory reaction and suggest that the synovium is a peculiarly “redox-sensitive” microenvironment. This discussion will be illustrated by a zonal model of tissue injury to represent the diseased synovium.

Sahinoglu T Stevens CR Blake DR

Number of references: 20

Language: Eng

Primary Author’s Address: London Hospital Medical College, U.K.

Country: SWEDEN

MeSH Headings: Animal Arthritis/physiopathology Human Joints/*metabolism/physiopathology Models, Biological/* Oxidation-Reduction Support, Non-U.S. Gov’t Synovial Membrane/*metabolism/physiopathology

Medlars UID 95265926

Article Notes:

Article speaks of arthritis as directly correlated to oxidative stress — bodily stress that is otherwise combatted by anti-oxidants.

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