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[General argyria caused by administration of tobacco-withdrawal tablets containing silver acetate]

Ned Tijdschr Geneeskd, 139: 51, 1995 Dec 23, 2658-61

 

 

Abstract

In a 49-year-old man generalised argyria was diagnosed, a systemic dissemination and tissue deposition of silver in the body. The clinical picture was brought about by use of a silver acetate-containing lozenge as a deterrent to smoking. Argyria is characterised by a slate blue-gray discolouration of the skin, particularly in areas exposed to light. Generally, it causes patients a great deal of anguish and embarrassment. Present understanding is that it does not entail non-cutaneous, systemic effects. There is no effective treatment--the discolouration is permanent. Currently, prevention is the only possible measure. Efforts should be made to eliminate the uncontrolled use of silver-containing preparations.

 

Van Garsse L; Versieck J

 

 

Language of Publication

Dutch

Original Title

Veralgemeende argyrose door het gebruik van tabak-ontwenningstabletten met zilveracetaat.

Address

Algemeen Ziekenhuis Sint-Blasius, afd. Inwendige Ziekten, Dendermonde, België.

Unique Identifier

96146220

MeSH Heading (Major)

Acetic Acids [*AE], Ammonium Chloride [*AE], Argyria [BL/*ET], Smoking [*PC]

MeSH Heading

Case Report, Drug Combinations, Drugs, Non-Prescription [AE], English Abstract, Human, Male, Middle Age, Silver [BL]

Publication Type

JOURNAL ARTICLE

ISSN

0028-2162

Country of Publication

NETHERLANDS

CAS Registry/EC Number

0 (Acetic Acids)
0 (Drug Combinations)
0 (Drugs, Non-Prescription)
12125-02-9 (Ammonium Chloride)
64-19-7 (acetic acid glacial)
7440-22-4 (Silver)
79234-31-4 (respaton)