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author: Discusses it's use in strengthening the immune system.
Immunomodulation by pycnogenol in retrovirus-infected or ethanol-fed mice. Life Sci Vol. 58 no. 5 pp. PL 87-96
MedlineŽ DATE: 1996 AbstractPycnogenol is a commercial mixture of bioflavonoids that exhibits antioxidative activity. The effects of dietary pycnogenol on immune dysfunction in normal mice as well as those fed ethanol or infected with the LP-BM5 murine retrovirus were determined. The ethanol consumption and retrovirus infection caused abnormalities in the function and/or structure of a broad array of cells involved in humoral and cellular immunity. Pycnogenol enhanced in vitro IL-2 production by mitogen-stimulated splenocytes if its production was suppressed in ethanol-fed or retrovirus-infected mice. Mitogenesis of splenocytes did not show a significant change in mice treated with pycnogenol. It reduced the elevated levels of interleukin-6 produced in vitro by cells from retrovirus infected mice and IL-10 secreted by spleen cells from mice consuming ethanol. Natural killer cell cytotoxicity was increased with pycnogenol treatment.
Primary Author's Address: Department of Family and Community Medicine, University of Arizona, Tucson 85724, USA. Language: Eng Country: ENGLAND MeSH Headings: Adjuvants, Immunologic/*pharmacology Alcohol, Ethyl/*pharmacology Alcoholism/immunology Animal Antibody Formation/drug effects Bioflavonoids/*pharmacology Cytokines/analysis/biosynthesis Cytotoxicity, Immunologic/drug effects Enzyme-Linked Immunosorbent Assay Female Immunity, Cellular/drug effects Killer Cells, Natural/drug effects/immunology Leukemia, Experimental Liver/metabolism Lymphocyte Transformation/drug effects Mice Mice, Inbred C57BL/MICE INBRED CA57BL Murine Acquired Immunodeficiency Syndrome/*immunology Spleen/immunology Support, Non-U.S. Gov't Vitamin E/metabolism Medlars UID 96173233 |