Comments from Website author: Article concludes that
Pycnogenol (procyanidin & procyanidol) binds to skin elastin and "markedly"
reduces it's degradation by the elastase of the inflammatory process. (Anything which ends
in "..ase" is that compound which "breaks apart" the root term. E.g.
"elastin-ase".)
Comments from Physicians at this article's end: None
Evidence by in vivo and in vitro studies that
binding of pycnogenols to elastin affects its rate of degradation by elastases.
Biochem Pharmacol, 33: 24, 1984 Dec 15, 3933-9
- Abstract
- Procyanidol oligomers and (+) catechin bound to insoluble
elastin markedly affect its rate of degradation by elastases. Insoluble elastin pretreated with procyanidol oligomers (PCO) was
resistant to the hydrolysis induced by both porcine pancreatic and human leukocyte
elastases. The quantitative adsorption of pancreatic elastase was similar on either
untreated or PCO-treated elastin suggesting that the binding of this compound to elastin
increases the non-productive catalytic sites of elastase molecules. (+) Catechin-insoluble
elastin complexes were partially resistant to the degradation induced by human leukocyte
elastase but were hydrolysed at the same rate as untreated samples by a constant amount of
pancreatic elastase. In addition, the coacervation profile of kappa-elastin peptides as a
function of temperature is greatly modified in presence of these flavonoids. We
conclusively evidenced that PCOs bind to skin elastic fibres when injected intradermally
into young rabbits. As a result, these elastic fibres were found more resistant to the
hydrolytic action of porcine pancreatic elastase when injected to the same site. These in vivo studies further emphasized the potential effect of
these compounds in preventing elastin degradation by elastase(s) as occurred in
inflammatory processes.
-
- Tixier JM; Godeau G; Robert AM; Hornebeck W
-
- Language of Publication
- English
- Unique Identifier
- 85072313
- MeSH Heading (Major)
- Benzopyrans [ME/*PD], Elastin [*ME],
Pancreatopeptidase [*PD]
- MeSH Heading
- Animal, In Vitro, Rabbits, Support, Non-U.S. Gov't,
Temperature
- Publication Type
- JOURNAL ARTICLE
- ISSN
- 0006-2952
- Country of Publication
- ENGLAND
- CAS Registry/EC Number
- EC 3.4.21.36 (Pancreatopeptidase)
0 (pycnogenols)
0 (Benzopyrans)
9007-58-3 (Elastin)