Comments from Website author: Proanthocyanidin is the chemical name of Pycnogenol. This article discusses how Pycnogenol's component chemical compounds reduces the ornithine decarboxylase (ODC) marker of skin tumor promotion
Comments from Physicians at this article's end: None

Ability of m-chloroperoxybenzoic acid to induce the ornithine decarboxylase marker of skin tumor promotion and inhibition of this response by gallotannins, oligomeric proanthocyanidins, and their monomeric units in mouse epidermis in vivo.

Anticancer Res 15: 1183-1189 (1995)[95382557]

Anti-Cancer Drug Laboratory, Kansas State University, Manhattan 66506-4901, USA.

Abstract

m-Chloroperoxybenzoic acid (CPBA) was tested for its ability to induce the ornithine decarboxylase (ODC) marker of skin tumor promotion. In contrast to benzoyl peroxide, dicumyl peroxide, and 2-butanol peroxide, 5 mg of CPBA applied twice at a 72-h interval induce ODC activity at least as much as 3 micrograms of 12-O-tetradecanoylphorbol-13-acetate (TPA). ODC induction peaks 36 h after a single CPBA treatment but is maximal 5 h after two applications of CPBA at a 48-h interval. The ODC-inducing activity of CPBA is dose dependent and sustained after chronic treatment. In contrast to TPA, two CPBA treatments at 12-24 h intervals produce no refractory state against ODC induction. The mechanism of ODC induction by CPBA is iron dependent. Various hydrolyzable tannins, condensed tannins (CTs) and their monomeric units remarkably inhibit the ODC response to multiple CPBA treatments. At 12 mg, gallic acid, Aleppo gall tannic acid (TA), catechin, and loblolly pine bark CT inhibit the most CPBA-induced ODC activity. Aleppo gall TA is even effective when applied several hours before CPBA. The tumor-promoting activity of CPBA and its inhibition by plant tannins remain to be evaluated.

G. Chen, E. M. Perchellet, X. M. Gao, S. W. Newell, R. W. Hemingway, V. Bottari & J. P. Perchellet

MeSH Terms:

Animal, Anthocyanins/pharmacology, Chlorobenzoates/toxicity, Enzyme Induction/drug effects, Female, Mice, Ornithine Decarboxylase/biosynthesis, Skin/enzymology, Skin, Neoplasms/chemically induced, Skin Neoplasms/enzymology, Skin Neoplasms/prevention & control, Support, Non-U.S. Gov't, Support, U.S. Gov't, Non-P.H.S.; Support, U.S. Gov't, P.H.S.; Tannic Acid/pharmacology, Tetradecanoylphorbol Acetate/toxicity,

Substances:

Tetradecanoylphorbol Acetate, Ornithine Decarboxylase, Chlorobenzoates, Tannic Acid, 3-chloroperbenzoic acid, Anthocyanins, proanthocyanidin